MCAS sufferer here, who had to circumvent my own doctors to get blood/urine tests proving elevated tryptase, prostaglandin, IgE, etc, which did not go over well with their egos. For 23 years doctors told me I was a hypochondriac and needed a shrink. Vindication eventually, but 2 decades of my life were wasted arguing with those pompous blowhards, so that "victory" means little.
This may not apply to you, as everyone is unique, but excipients, dyes and fillers in prescribed and OTC meds and supplements can be major triggers for some people with MCAS. Red dye is in most pills, (bleached white) and often under names like "Aluminum Lake" and 100s of others. Microcrystalline cellulose is another that affects some of us, and it's in just about everything. My point is, if you hit a "wall" after eating "clean" and all the rest, consider what's in meds and supplements, and possibly even skin care and makeup. I'm a "dude", so know nothing about that, whereas for females that use those products, topical transdermal "pollution" into the body via those products is possible, even suppositories are known to have ingredients that bother some people due to "booty" skin absorption.
Lack of sleep due to elevated histamine, fluorescent lights in schools and just about any commercial building, inability to concentrate in class or work, all can have a detrimental effect on your quality of life, plus can cause anxiety, stress, etc. Anyway, most people with MCAS and related diseases are going to struggle trying to get proper medical care at this point in time. And I really wish the medical establishment would grasp what idiopathic means, as in things cycle, migrate, change and are not always constant so certain tests are not always going to reveal symptoms. It would help if they would use critical thinking skills rather than rely on rote memorization only. Okay, enough bloviating out of me. :)
